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Related Concept Videos

Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

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Related Experiment Video

Updated: May 31, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

Endocrine pancreatic function changes after acute pancreatitis.

Deqing Wu1, Yaping Xu, Yue Zeng

  • 1Department of Gastroenterology, The 10th People's Hospital Affiliated to Shanghai Tongji University, Shanghai, China.

Pancreas
|June 28, 2011
PubMed
Summary
This summary is machine-generated.

Pancreatic endocrine function impairment, including insulin resistance, is common after acute pancreatitis. Obesity and hyperlipidemia significantly increase the risk of developing this functional impairment.

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Metabolic Diseases

Background:

  • Acute pancreatitis (AP) can lead to long-term complications affecting pancreatic function.
  • Understanding the sequelae of AP on endocrine and exocrine functions is crucial for patient management.

Purpose of the Study:

  • To investigate pancreatic endocrine function impairment after AP.
  • To identify risk factors associated with endocrine insufficiency post-AP.

Main Methods:

  • Evaluated pancreatic endocrine function in 59 AP patients (mean 3.5 years post-event) using fasting blood glucose, HbA1c, insulin, C-peptide, and HOMA.
  • Assessed pancreatic exocrine function via fecal elastase 1.
  • Investigated potential influencing factors on endocrine function.

Main Results:

  • 32% of patients had elevated fasting blood glucose; 8% had abnormal HbA1c.
  • AP patients showed higher fasting blood glucose, insulin, C-peptide, and insulin resistance, with lower islet β-cell function compared to controls.
  • Obesity, hyperlipidemia, and diabetes symptoms correlated with endocrine insufficiency; exocrine impairment was also observed.

Conclusions:

  • Pancreatic endocrine dysfunction, characterized by insulin resistance, is prevalent post-AP.
  • Obesity, hyperlipidemia, and diabetes symptoms are key risk factors for developing endocrine impairment after AP.