Related Experiment Video
Updated: May 31, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Routine stress testing after percutaneous coronary interventions
A Patel1, A H Waller, A Rusovici
1Division of Cardiology, University Hospital Medical Center, New Jersey Medical School, Newark, NJ 07101, USA.
Insights
Routine stress testing after percutaneous coronary intervention (PCI) is not recommended for stable, asymptomatic patients. Selective testing may benefit high-risk individuals for in-stent restenosis or major adverse cardiac events.
Area of Science:
- Cardiology
- Interventional Cardiology
Background:
- Percutaneous coronary intervention (PCI) is a common cardiovascular procedure.
- Historically, routine stress testing post-PCI was standard practice.
- Advancements like drug-eluting stents have reduced major adverse cardiac events (MACE) and in-stent restenosis (ISR) rates.
Purpose of the Study:
- To review the role of stress testing in patients after PCI.
- To evaluate the necessity of routine stress testing in asymptomatic post-PCI patients.
- To determine appropriate indications for stress testing in the post-PCI setting.
Main Methods:
- Literature review and synthesis of current evidence.
- Analysis of the benefits versus risks of routine post-PCI stress testing.
- Evaluation of diagnostic yield in relation to patient symptoms and risk factors.
Main Results:
- Reduced rates of MACE and ISR (<10%) in the first year post-PCI.
- Lowered pre-test probability of post-PCI ischemia in asymptomatic patients.
- Potential harms of routine testing include arrhythmias, infarction, death, radiation exposure, and unnecessary interventions.
Conclusions:
- Routine stress testing in clinically stable, asymptomatic post-PCI patients should be discouraged.
- Selective stress testing is appropriate for high-risk patients for ISR or MACE.
- Stress testing can guide clinical decisions and refine care in select patient populations.
Abstract:
Percutaneous coronary intervention (PCI) is the most frequently performed cardiovascular procedure. Many physicians caring for post-PCI patients have routinely subjected patients to periodic stress testing. In the recent years, due to widespread use of drug eluting stents the combined rates of major adverse cardiac events (MACE) and in-stent restenosis (ISR) dropped <10% in the initial 12 months post-PCI, with only half of these patients bearing symptoms. This has translated into reduced pre-test probability of post-PCI ischemia. Consequently, the beneficial effect of this practice came into question. Moreover, in addition to its financial implications, routine post-PCI stress testing may carry potential harm: medication or exercise induced arrhythmia, infarction and/or death, patient irradiation exposure, false-positive tests resulting in excessive invasive testing or interventions, and the illusion of "wellness" in the face of a somewhat unpredictable disease. This review addresses the role stress testing post-PCI: it is concluded that routine stress testing in clinically stable asymptomatic post-PCI patients should be discouraged. Selective utilization of stress testing in patients with exceptionally high risk of ISR or MACE can be utilized to answer important clinical questions or guide and refine clinical care.
Related Concept Videos
Exercise Stress Test
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Coronary Artery Disease V: Interprofessional Care
Acute Coronary Syndrome III: Diagnostic Studies
Acute Coronary Syndrome IV: Interprofessional Care
Cardiac Catheterization IV: Nursing Management
Cardiac Catheterization I: Pre-Procedure Overview