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Updated: May 31, 2026

Retroperitoneal Laparoscopic Debridement and Drainage for Pancreatic Abscess
Published on: March 15, 2024
[Peritonitis due to post-myomectomy Mycoplasma hominis infection]
Yosuke Tanaka1, Yuko Sasaki, Akihito Wada
1Department of Clinical Laboratory, St Marianna University School of Medicine, Yokohama City Seibu Hospital.
Abstract:
A 36-year-old woman undergoing a myomectomy developed postoperative surgical-saite peritonitis and hematoma. Eight days postoperatively, she developed a 38 degrees C-plus fever and accumulated ascites, with fever unchanged despite antimicrobial beta-lactams therapy. Following transvaginal ascitic drainage, her fever disappeared. Recurrent 38 degrees C fever and inflammation were cured by clindamycin of 1.2 g/day. M. hominis detected from ascites drainage was considered the primary causative organism. Nongenito-urinary M. hominis infection is often difficult to detect, as in our case. Gram staining, for example, is not useful in ascertaining small organisms such as Mycoplasma spp. having no cell walls to stain. M. hominis grows slowly, requiring over three days to form colonies on blood agar plates, requiring time to identify pathogens. We report case showing the importance of suspecting M. hominis of causing gynecological surgical-site infection. When common bacterial pathogen cultures remain negative and when empiric beta-lactam antibiotic treatment is ineffective, M. hominis should be suspected. In conclusion, M. hominis should be considered a causative following myomectomy resection.
Insights
Mycoplasma hominis (M. hominis) can cause difficult-to-diagnose gynecological surgical site infections after myomectomy. Suspect M. hominis when standard treatments fail and cultures are negative.
Area of Science:
- Gynecology
- Infectious Diseases
- Microbiology
Background:
- Myomectomy is a common surgical procedure for uterine fibroids.
- Postoperative complications can include surgical site infections.
- Identifying the causative agent is crucial for effective treatment.
Observation:
- A patient developed fever and ascites post-myomectomy, unresponsive to beta-lactams.
- Transvaginal ascitic drainage temporarily resolved symptoms.
- Recurrent fever and inflammation were treated successfully with clindamycin.
Findings:
- Mycoplasma hominis (M. hominis) was identified as the causative agent from ascites.
- M. hominis infections are challenging to diagnose due to slow growth and lack of cell walls.
- Standard Gram staining is ineffective for Mycoplasma species.
Implications:
- M. hominis should be suspected in gynecological surgical site infections when conventional treatments fail.
- Diagnostic methods need to accommodate slow-growing organisms like M. hominis.
- Early and accurate diagnosis of M. hominis is vital for successful patient outcomes.
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