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Related Experiment Videos

[Anticoagulant therapy in obstetrical disorders].

M Murata1, M Hayakawa, K Goto

  • 1Department of Obstetrics and Gynecology, Akita University School of Medicine.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|June 1, 1990
PubMed
Summary

Antithrombin-III (AT) therapy improved platelet counts and fibrinogen levels in obstetrical disseminated intravascular coagulation (DIC). AT and low molecular weight heparin (LMWH) showed promise in treating related conditions like abruptio placentae and intrauterine growth retardation.

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Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Pharmacology

Context:

  • Disseminated intravascular coagulation (DIC) is a serious complication in obstetrics.
  • Specific conditions like abruptio placentae, toxemia pregnancy, and intrauterine growth retardation (IUGR) are associated with DIC.
  • Evaluating the efficacy of different anticoagulant therapies is crucial for managing these obstetric emergencies.

Purpose:

  • To investigate the effectiveness of three anticoagulant therapy regimens for obstetrical DIC.
  • To compare Antithrombin-III (AT) or gabexate mesilate for acute DIC.
  • To assess heparin or heparin-AT combination therapy for toxemia pregnancy and low molecular weight heparin (LMWH) for IUGR.

Summary:

  • Antithrombin-III (AT) therapy led to significant increases in platelet count and fibrinogen compared to gabexate mesilate, with notable improvements in renal failure and hemorrhagic diathesis.

Related Experiment Videos

  • In cases of toxemia pregnancy, heparin-AT combination therapy showed improvement in systolic blood pressure, with concurrent detection of thrombin-antithrombin complex.
  • Low molecular weight heparin (LMWH) administration resulted in improved fetal body weight gain and blood flow redistribution in fetuses with severe intrauterine growth retardation (IUGR).

    • Impact:

    • Antithrombin-III (AT) demonstrates potential as a superior treatment for acute obstetrical DIC, particularly in abruptio placentae.
    • Combination therapy with heparin and AT may offer benefits in managing toxemia pregnancy-related hypertensive conditions.
    • Low molecular weight heparin (LMWH) shows promise in improving fetal outcomes for intrauterine growth retardation (IUGR).