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Updated: May 31, 2026

Rat Model of Closed-Head Mild Traumatic Injury and its Validation
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Rodent under the hat.

William B Lo1, Lewys Richmond, K Joshi George

  • 1Department of Neurosurgery, University Hospital, Coventry, UK. williamlo@doctors.org.uk

British Journal of Neurosurgery
|June 29, 2011
PubMed
Summary
This summary is machine-generated.

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A neglected scalp basal cell carcinoma (BCC) caused extensive tissue and bone destruction but spared the brain. This rare case highlights BCC

Area of Science:

  • Dermatology
  • Oncology
  • Neurosurgery

Background:

  • Basal cell carcinoma (BCC) is a common skin cancer, rarely presenting with extensive local destruction.
  • Neglected BCC can lead to significant morbidity, affecting soft tissues and bone.

Observation:

  • A 57-year-old woman presented with a neglected scalp BCC causing total soft tissue and cranial bone destruction.
  • The lesion was hidden for 9 months due to embarrassment, with no signs of meningitis or intracranial spread.
  • Despite extensive destruction, the dura mater remained intact, and there was no brain parenchymal involvement.

Findings:

  • Biopsy confirmed BCC.
  • The patient underwent successful reconstruction with latissimus dorsi flaps and palliative radiotherapy.
  • The case offers insights into the natural history of neglected scalp BCC and factors contributing to its rarity and lack of intracranial infection.

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Implications:

  • This case underscores the importance of early detection and treatment of skin cancers, even on the scalp.
  • It highlights the potential for aggressive local invasion of BCC while maintaining a low risk of intracranial complications in some instances.
  • Further research into the factors protecting the dura and brain in such advanced cases is warranted.