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Updated: Jan 14, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

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Systemic therapy for sarcomatoid renal cell carcinoma.

Lance C Pagliaro¹, Nizar Tannir, Kanishka Sircar

¹Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, USA. lpagliar@mdanderson.org

Expert Review of Anticancer Therapy

|June 29, 2011

Summary

Sarcomatoid renal cell carcinoma (RCC) is an aggressive kidney cancer variant. New treatments are being investigated due to limited effectiveness of current therapies for this lethal disease.

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Area of Science:

Oncology
Nephrology
Genetics

Background:

Renal cell carcinoma (RCC) is the most common kidney malignancy.
Sarcomatoid RCC is an aggressive and lethal variant, not a distinct histologic type.
No specific biomarkers for sarcomatoid RCC have been identified.

Purpose of the Study:

To review the characteristics of sarcomatoid RCC.
To discuss the challenges in treating sarcomatoid RCC.
To highlight ongoing research for sarcomatoid RCC therapies.

Main Methods:

Literature review of sarcomatoid RCC.
Analysis of treatment efficacy in sarcomatoid RCC.
Overview of current clinical trials for sarcomatoid RCC.

Main Results:

Sarcomatoid features are observed across various RCC subtypes.
Current systemic therapies show reduced efficacy in sarcomatoid RCC.
Cytotoxic drugs may offer potential due to rapid proliferation.

Conclusions:

Sarcomatoid RCC presents unique therapeutic challenges.
Further research is crucial for effective treatment strategies.
Ongoing clinical trials aim to improve outcomes for sarcomatoid RCC patients.