Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
Inhibitors of Bacterial Protein Synthesis01:25

Inhibitors of Bacterial Protein Synthesis

Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
Methods for Controlling Microbial Growth01:29

Methods for Controlling Microbial Growth

Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
Automated Microbial Diagnostics01:24

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trigger Factor in <i>Burkholderia pseudomallei</i> is essential for key virulence determinants, including host cell internalization, cytotoxicity, motility, and stress resistance.

Journal of bacteriology·2026
Same author

Inhaled Ciprofloxacin as an Alternative Treatment for Infection with <i>Coxiella burnetii</i>.

Antibiotics (Basel, Switzerland)·2026
Same author

High Affinity Inhibitors of the Macrophage Infectivity Potentiator Protein from <i>Trypanosoma cruzi</i>, <i>Burkholderia pseudomallei</i>, and <i>Legionella pneumophila</i>─A Comparison.

ACS infectious diseases·2024
Same author

Identification of active main metabolites of anti-infective inhibitors of the macrophage infectivity potentiator protein by liquid chromatography using mass detection.

Archiv der Pharmazie·2024
Same author

Inhibition of macrophage infectivity potentiator in <i>Burkholderia pseudomallei</i> suppresses pro-inflammatory responses in murine macrophages.

Frontiers in cellular and infection microbiology·2024
Same author

N-acetyl-β-hexosaminidase activity is important for chitooligosaccharide metabolism and biofilm formation in Burkholderia pseudomallei.

Environmental microbiology·2024
Same journal

Applications of lupeol to manage fungal infections: a promising multi-target molecule.

Future microbiology·2026
Same journal

Benzyl isothiocyanate-loaded chitosan beads: a novel strategy to combat biofilm formation by <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>.

Future microbiology·2026
Same journal

<i>Mycobacterium colombiense</i> isolation among people living with human immunodeficiency virus: a case series.

Future microbiology·2026
Same journal

Thwarting the biothreat in the 21st century: means and methods.

Future microbiology·2026
Same journal

The oral-respiratory interface: modulation of <i>Streptococcus pneumoniae</i> serotype adhesion by the periodontal pathogen <i>Porphyromonas gingivalis</i> W83.

Future microbiology·2026
Same journal

Global One Health genomics identify conserved virulence and mobile resistance in the opportunistic pathogen <i>Staphylococcus saprophyticus</i>.

Future microbiology·2026
See all related articles

Related Experiment Video

Updated: May 31, 2026

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
09:29

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Published on: April 28, 2017

Antimicrobials for bacterial bioterrorism agents.

Mitali Sarkar-Tyson1, Helen S Atkins

  • 1Biomedical Sciences Department, Defence Science & Technology Laboratory, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.

Future Microbiology
|June 29, 2011
PubMed
Summary
This summary is machine-generated.

New antimicrobials are needed to combat bioterrorism agents due to current drug limitations. Targeting bacterial virulence, like type III secretion systems, shows promise for developing broad-spectrum countermeasures.

More Related Videos

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
09:17

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

Related Experiment Videos

Last Updated: May 31, 2026

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
09:29

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Published on: April 28, 2017

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
09:17

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

Area of Science:

  • Microbiology
  • Pharmacology
  • Biodefense

Background:

  • Current antimicrobials face limitations against highly virulent pathogens.
  • Emerging infectious diseases and potential bioterrorism necessitate novel therapeutic strategies.
  • Bacterial pathogens pose significant threats, especially those designated as bioterrorism agents.

Purpose of the Study:

  • To highlight the urgent need for new antimicrobial agents effective against bioterrorism pathogens.
  • To explore antivirulence strategies as a promising approach for developing novel countermeasures.
  • To identify specific bacterial mechanisms that represent viable targets for therapeutic intervention.

Main Methods:

  • Review of existing literature on antimicrobial limitations and bioterrorism threats.
  • Analysis of antivirulence strategies targeting bacterial pathogenicity mechanisms.
  • Evaluation of inhibitors targeting type III secretion systems and cell division as potential drug candidates.

Main Results:

  • Limitations of current antimicrobials necessitate the development of new agents.
  • Antivirulence strategies offer a promising avenue for combating bacterial bioterrorism agents.
  • Inhibitors of type III secretion systems and cell division mechanisms show potential efficacy.

Conclusions:

  • Development of novel antimicrobials is critical for biodefense applications.
  • Targeting bacterial virulence mechanisms, such as type III secretion and cell division, represents a viable therapeutic strategy.
  • Antivirulence approaches hold promise for future countermeasures against broad-spectrum bacterial pathogens.