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Updated: May 31, 2026

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Published on: September 16, 2012

Red cell concentrate storage and transport temperature.

V Hancock¹, R Cardigan, S Thomas

¹Component Development Laboratory, NHS Blood and Transplant, Brentwood, Essex, UK. vicky.hancock@nhsbt.nhs.uk

Transfusion Medicine (Oxford, England)

|June 29, 2011

Summary

This summary is machine-generated.

Red cell concentrate (RCC) quality remains stable after temperature deviations during transport, meeting UK guidelines. Exposure to 10°C for up to 12 hours did not negatively impact RCC in vitro quality.

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Last Updated: May 31, 2026

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Area of Science:

Transfusion Medicine
Blood Product Quality Control
Biologics Storage and Handling

Background:

Current UK guidelines permit specific temperature deviations during red cell concentrate (RCC) transport.
Guidelines allow core temperatures between 1-10°C for <5 hours and surface temperatures of 2-10°C for ≤12 hours.

Purpose of the Study:

To investigate the impact of temperature deviations on the in vitro quality of SAGM-preserved red cell concentrates (RCC).
To assess compliance with UK storage and transport guidelines for RCC.

Main Methods:

Twenty RCC units in SAGM were tested for in vitro quality before and after temperature deviations.
Units were incubated at 10°C for either 12 hours or for two periods of 5 and 12 hours.
Quality testing extended up to 42 days of storage.

Main Results:

Haemolysis remained below the UK limit of 0.8% at day 42 in all units.
Supernatant potassium levels were significantly elevated by day 35 and 42.
Adenosine triphosphate and 2,3-diphosphoglycerate levels remained comparable to reference data.

Conclusions:

Exposure to 10°C for 12 hours, or for 5 and 12 hours, did not adversely affect in vitro red cell quality.
The findings support the current UK guidelines for RCC transport temperature excursions.