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A CTSA agenda to advance methods for comparative effectiveness research.
Mark Helfand1, Sean Tunis, Evelyn P Whitlock
1Oregon Clinical & Translational Research Center, Oregon Health & Sciences University, and Department of Hospital and Specialty Medicine, The Portland VA Medical Center, Portland, OR, USA. helfand@ohsu.edu
Clinical and Translational Science
|June 29, 2011
Summary
Patient-centered outcomes research (PCOR) requires improved methods for identifying research questions, designing studies, and integrating practice into research priorities. This enhances the relevance and applicability of clinical research for all stakeholders.
Area of Science:
- Clinical research methodology
- Comparative Effectiveness Research (CER)
- Patient-Centered Outcomes Research (PCOR)
Background:
- Clinical research must become more valuable to patients, clinicians, and decision-makers.
- There is a need for research that focuses on patient-centered outcomes, compares alternatives, and respects patient individuality.
- Comparative Effectiveness Research (CER) is inherently patient-centered, necessitating advancements in research methods.
Purpose of the Study:
- To outline 10 priority areas addressing critical needs in Patient-Centered Outcomes Research (PCOR).
- To propose improvements in the development, testing, and application of CER methods.
- To enhance the linkage between clinical practice and research priorities for PCOR.
Main Methods:
- Identification of 10 priority areas for PCOR methods research.
- Focus on three critical needs: question prioritization, study design/conduct/analysis, and practice-research linkage.
- Argument for NIH to integrate methods research with large-scale clinical and health system studies.
Main Results:
- Defined key areas for advancing PCOR methods.
- Highlighted the importance of trustworthy methods for prioritizing research questions.
- Emphasized the need for better study designs and integration of practice data.
Conclusions:
- Accelerating the development and refinement of CER methods is crucial.
- Linking methods research with prospective studies will yield valuable insights.
- NIH's clinical and translational research program can drive progress in CER and PCOR.
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