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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Cross-reactivity00:42

Cross-reactivity

Overview

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Related Experiment Video

Updated: May 31, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Predicting which medication classes interfere with allergy skin testing.

Kunal M Shah1, Matthew A Rank, Shoban A Davé

  • 1Division of Allergic Diseases, Mayo Clinic, Rochester, Minnesota, USA. shah.kunal@mayo.edu

Allergy and Asthma Proceedings
|June 29, 2011
PubMed
Summary
This summary is machine-generated.

Many medications interfere with allergy skin tests. Tricyclic antidepressants (TCAs), H(1)-blockers, and benzodiazepines significantly impact results. Selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and proton pump inhibitors (PPIs) are unlikely to interfere.

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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Published on: April 21, 2019

Related Experiment Videos

Last Updated: May 31, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

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Published on: May 31, 2021

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Published on: April 21, 2019

Area of Science:

  • Allergy and Immunology
  • Pharmacology

Background:

  • Medication use can complicate allergy skin test interpretation.
  • Identifying interfering medications is crucial for accurate allergy diagnosis.

Purpose of the Study:

  • To determine which common medications interfere with allergy skin test results.
  • To provide guidance on medication discontinuation prior to skin testing.

Main Methods:

  • Retrospective review of skin-prick test results.
  • Analysis of patients who discontinued various medications (H(1)-antagonists, TCAs, SSRIs, SNRIs, benzodiazepines, PPIs, H(2)-antagonists) before testing.
  • Evaluation of histamine control response in relation to medication use.

Main Results:

  • Tricyclic antidepressants (TCAs), H(1)-blockers, and benzodiazepines were associated with a significantly higher odds of a negative histamine test.
  • Selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and proton pump inhibitors (PPIs) showed minimal interference.
  • Certain atypical antidepressants and sedatives also demonstrated interference with histamine response.

Conclusions:

  • TCAs, H(1)-blockers, and benzodiazepines should be temporarily discontinued if clinically feasible before allergy skin testing.
  • SSRIs, SNRIs, and PPIs are unlikely to interfere, allowing continued use.
  • Further consideration is needed for atypical antidepressants and sedatives regarding skin test interference.