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A New Method for Inducing a Depression-Like Behavior in Rats

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Published on: February 22, 2018

Social rhythms and vulnerability to bipolar disorder.

Ben Bullock¹, Fiona Judd, Greg Murray

¹Australian Catholic University, Melbourne, Australia. ben.bullock@acu.edu.au

Journal of Affective Disorders

|June 29, 2011

Summary

Reduced social rhythmicity was observed in individuals with higher bipolar disorder vulnerability, but not in clinical outpatients compared to low-vulnerability groups. This finding impacts managing bipolar disorder risk.

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Area of Science:

Psychiatry
Chronobiology
Bipolar Disorder Research

Background:

Reduced social rhythmicity is a hallmark of bipolar disorder.
This feature may also be present in individuals at risk for bipolar disorder.

Purpose of the Study:

To investigate social rhythms in bipolar disorder outpatients and non-clinical groups with high and low vulnerability.
To determine if reduced social rhythmicity differentiates clinical and at-risk groups.

Main Methods:

Three groups were studied: bipolar disorder outpatients (n=15), and non-clinical high (n=36) and low (n=36) vulnerability groups.
Participants completed a daily self-report social rhythmicity measure for seven days.

Main Results:

A significant overall group effect was found for social rhythmicity (F(2,83)=4.67, p<.05).
Post hoc tests revealed significant differences only between the two non-clinical groups.

Conclusions:

The hypothesis was partially supported: higher vulnerability non-clinical group showed lower social rhythmicity than the low vulnerability group.
The clinical group did not differ from the low vulnerability group in social rhythmicity.
Findings suggest implications for managing bipolar disorder vulnerability.