Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hormone replacement therapy and lipoprotein changes during early menopause.

G M Egeland1, L H Kuller, K A Matthews

  • 1Department of Epidemiology, University of Pittsburgh, Pennsylvania.

Obstetrics and Gynecology
|November 1, 1990
PubMed
Summary

Postmenopausal hormone therapy, including estrogen alone or with progestogen, may offer cardiovascular benefits. It helps protect against harmful changes in low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol levels seen in non-users.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum non-esterified fatty acid levels and hip fracture risk: The Cardiovascular Health Study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Intercensal and Postcensal Estimation of Population Size for Small Geographic Areas in the United States.

International journal of population data science·2021
Same author

Racial/Ethnic Differences in Women's Life Event Exposure Across Midlife.

The journals of gerontology. Series B, Psychological sciences and social sciences·2021
Same author

Hospitalised patients with unexplained chest pain: incidence and prognosis.

Journal of internal medicine·2019
Same author

The effect of insulin on bone mineral density among women with type 2 diabetes: a SWAN Pharmacoepidemiology study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2017
Same author

Depression, telomeres and mitochondrial DNA: between- and within-person associations from a 10-year longitudinal study.

Molecular psychiatry·2017

Area of Science:

  • Endocrinology
  • Cardiovascular Health
  • Lipid Metabolism

Background:

  • Menopause is associated with changes in lipoprotein profiles, potentially increasing cardiovascular disease risk.
  • Hormone replacement therapy (HRT) is used to manage menopausal symptoms, but its effects on cardiovascular risk factors require further elucidation.
  • Understanding HRT's impact on lipids is crucial for assessing its overall cardiovascular benefit.

Purpose of the Study:

  • To investigate the effects of postmenopausal hormone replacement therapy on lipoprotein levels.
  • To compare lipid changes in estrogen-only users, estrogen-progestogen users, and non-users during the menopausal transition.

Main Methods:

  • A cohort of 211 healthy premenopausal women was followed through menopause.
  • Lipoprotein levels, including LDL cholesterol and HDL cholesterol, were monitored over time.

Related Experiment Videos

  • Changes in apolipoproteins and triglycerides were also assessed in relation to HRT use.

    • Main Results:

    • Estrogen and estrogen-progestogen users showed minimal increases in low-density lipoprotein (LDL) cholesterol compared to significant increases in non-users.
    • Estrogen users had a slight increase in high-density lipoprotein (HDL) cholesterol, while estrogen-progestogen users maintained premenopausal HDL levels; non-users experienced HDL decreases.
    • Both HRT groups exhibited increases in apolipoprotein AI, apolipoprotein AII, and triglycerides relative to non-users.

    Conclusions:

    • Estrogen, with or without medroxyprogesterone acetate, may offer cardiovascular benefits by mitigating atherogenic changes in LDL and HDL cholesterol.
    • HRT appears to protect against unfavorable lipid profile shifts associated with menopause.
    • Despite triglyceride increases, HRT's overall impact on lipid profiles suggests a potential benefit for coronary heart disease risk reduction.