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Related Experiment Video

Updated: May 31, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Mortality rate in patients with diastolic dysfunction and normal systolic function.

Carmel M Halley¹, Penny L Houghtaling, Mazen K Khalil

¹Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Archives of Internal Medicine

|June 29, 2011

Summary

In patients with normal systolic function, moderate to severe diastolic dysfunction (DD) independently predicts mortality. Mild DD, however, does not significantly impact survival rates in this population.

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Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

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Last Updated: May 31, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Area of Science:

Cardiology
Echocardiography
Prognostic Studies

Background:

Diastolic dysfunction (DD) is linked to higher mortality with impaired systolic function.
Prognostic data for DD in patients with normal systolic function are limited.

Purpose of the Study:

To investigate the prognostic impact of diastolic dysfunction (DD) in patients with normal systolic function.

Main Methods:

Retrospective review of 36,261 outpatient echocardiograms (1996-2005) with normal systolic function (ejection fraction ≥55%).
Diastolic function graded as normal, mild, moderate, or severe using echocardiographic Doppler variables.
Propensity analysis used to compare outcomes between groups.

Main Results:

Diastolic dysfunction was present in 65.2% of patients, with mild DD being most common.
Unadjusted survival rates worsened with increasing DD severity (P < .001).
After propensity matching, moderate (HR, 1.58) and severe (HR, 1.84) DD independently predicted increased mortality (P < .001 for each).

Conclusions:

Moderate and severe diastolic dysfunction are independent predictors of mortality in patients with normal ejection fraction.
Mild diastolic dysfunction, despite its prevalence, did not significantly affect survival in this cohort.