Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Karyotyping01:17

Karyotyping

Overview
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maple Syrup Urine Disease on the Newborn Screen: Don't Sugarcoat It.

Pediatrics in review·2026
Same author

Pharmacotherapy for alcohol misuse: Views of patients, providers, and leaders in an Alaska Native healthcare system.

Journal of substance use and addiction treatment·2026
Same author

Attitudes About Alcohol Misuse Among Alaska Native People in a Tribal Health Care System.

Journal of addiction medicine·2025
Same author

Parental Communication With their Children about Cancer Risk and DTC Cascade Genetic Testing: Implications for Genetic Education and Counseling.

American journal of medical genetics. Part A·2025
Same author

Pediatric DTC Genetic Testing for Adult-Onset Inherited Cancer Risk: The Perspectives of High-Risk Parents.

Public health genomics·2025
Same author

Ethics of Predicting and Preventing Preterm Birth.

Clinics in perinatology·2024
Same journal

Systematic review of environmental factors associated with severe fever with thrombocytopenia syndrome occurrences.

Epidemiologic reviews·2026
Same journal

How population-level drug supply data are integrated into health outcomes research: a scoping review.

Epidemiologic reviews·2026
Same journal

Exposure to air pollution and risk of gastrointestinal diseases: a systematic review and meta-analysis of epidemiological evidence.

Epidemiologic reviews·2026
Same journal

Digital solutions for tuberculosis surveillance and control in primary health care: a scoping review.

Epidemiologic reviews·2026
Same journal

Monitoring and evaluation of health disparities for people with disability in low- and middle-income countries: a scoping review.

Epidemiologic reviews·2026
Same journal

Current trends and future prospects of epidemiology of HPV-induced oropharyngeal cancer: a bibliometric analysis.

Epidemiologic reviews·2026
See all related articles

Related Experiment Video

Updated: May 31, 2026

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Genetic screening.

Wylie Burke1, Beth Tarini, Nancy A Press

  • 1Department of Bioethics and Humanities, A204 Health Sciences Building, Box 357120, University of Washington, Seattle, WA 98195, USA. wburke@u.washington.edu

Epidemiologic Reviews
|June 29, 2011
PubMed
Summary
This summary is machine-generated.

Genetic screening advances offer comprehensive insights beyond early disease detection, aiding reproductive choices and personalized prevention. However, new technologies introduce challenges like false positives and overdiagnosis, requiring careful consideration.

More Related Videos

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
09:33

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Related Experiment Videos

Last Updated: May 31, 2026

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
09:33

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Area of Science:

  • Genomics
  • Medical Genetics
  • Public Health

Background:

  • Traditional genetic screening focuses on early disease detection for preventive therapy.
  • Genetic screening has historically informed reproductive decisions.
  • Emerging technologies enable comprehensive identification of genetic traits and susceptibilities.

Purpose of the Study:

  • To analyze the evolving landscape of genetic screening.
  • To explore the implications of new technologies on screening goals.
  • To identify challenges and ethical considerations associated with expanded genetic screening.

Main Methods:

  • Review of current genetic screening approaches (newborn, reproductive, family history).
  • Analysis of how new technologies are reshaping screening objectives.
  • Discussion of potential benefits and challenges of comprehensive genetic information.

Main Results:

  • Genetic screening now aims to inform individuals about all genetic traits and susceptibilities.
  • New screening approaches support rapid diagnosis, family planning, and research.
  • Increased use of comprehensive genetic testing exacerbates existing challenges like false positives and overdiagnosis.

Conclusions:

  • Expanded genetic screening offers broader applications but introduces significant challenges.
  • Further empirical research is needed to evaluate the desirability of comprehensive genetic screening.
  • Careful deliberation among stakeholders is crucial for navigating the ethical and practical implications of novel screening approaches.