Decreased kidney function is a significant factor associated with silent cerebral infarction and periventricular

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Updated: May 31, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Hideaki Shima1, Eiji Ishimura, Toshihide Naganuma

  • 1Department of Endocrinology, Metabolism, Molecular Medicine and Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Kidney & Blood Pressure Research
|June 29, 2011
PubMed

Insights

Chronic kidney disease (CKD) is linked to silent cerebral lacunar infarction (SCI) and periventricular hyperintensities (PVH). Decreased kidney function increases the risk of these brain changes and future cerebrovascular events in CKD patients.

Area of Science:

  • Neurology
  • Nephrology
  • Vascular Medicine

Background:

  • Silent cerebral lacunar infarction (SCI) and periventricular hyperintensities (PVH) are established markers of ischemic cerebral small-vessel disease.
  • These conditions are recognized risk factors for future cerebrovascular events in the general population.

Purpose of the Study:

  • To investigate the relationship between chronic kidney disease (CKD) and the prevalence of SCI and PVH.
  • To determine if decreased kidney function is associated with SCI and PVH in predialysis CKD patients.

Main Methods:

  • A cross-sectional study involving 324 predialysis CKD patients and 60 healthy controls.
  • Brain magnetic resonance imaging (MRI) using a 1.5-T system was conducted for all participants.

Main Results:

  • SCI was detected in 31.8% and PVH in 53.7% of CKD patients.
  • The prevalence and grade of SCI/PVH increased with higher blood pressure, advanced age, and declining kidney function.
  • Estimated glomerular filtration rate (eGFR) was independently associated with the presence of SCI/PVH.

Conclusions:

  • Decreased kidney function in CKD patients is significantly associated with SCI and PVH.
  • SCI and PVH are strongly interrelated in the CKD population.
  • CKD patients with SCI/PVH face an elevated risk of future cerebrovascular events.
Abstract

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