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Published on: January 27, 2015
In vitro adherence of Candida albicans isolated from patients with chronic periodontitis
Adriana Gadotti Machado1, Edson Yukio Komiyama, Silvana Soléo Ferreira Dos Santos
1Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, State University of São Paulo, São José dos Campos, Brazil.
Unlabelled:
Adherence is considered an extremely important virulence factor in yeast.
Objective:
The aim of this study was to analyze the adherence to epithelial cells of C. albicans isolated from patients with chronic periodontitis in comparison to healthy patients.
Material And Methods:
Candida albicans cells isolated from individuals with chronic periodontitis (n=25) and healthy controls (n=25) were included in this study. Suspensions of C. albicans (10(6) cells/mL) and epithelial cells (10(5) cells/mL) were mixed and incubated at 37ºC for 1 h. The number of yeasts adhered to 25 epithelial cells was counted.
Results:
The number of C. albicans cells adhered to epithelial cells was statistically higher in the chronic periodontitis group than in the control group (Student's t-test, p=0.000).
Conclusion:
The results of the present study suggest a higher Candida adherence of samples isolated from patients with chronic periodontitis.
