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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: May 31, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Inflammatory bowel disease associated arthropathy.

Sheila L Arvikar1, Mark C Fisher

  • 1Department of Medicine, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.

Current Reviews in Musculoskeletal Medicine
|June 29, 2011
PubMed
Summary
This summary is machine-generated.

Arthritis is a common complication of inflammatory bowel disease (IBD), impacting quality of life. Understanding the unclear mechanisms of IBD-associated arthropathy is crucial for developing effective treatments.

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Last Updated: May 31, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

  • Rheumatology and Gastroenterology
  • Immunology and Genetics

Background:

  • Arthritis is the most frequent extraintestinal manifestation of inflammatory bowel disease (IBD).
  • IBD-associated arthropathy presents as axial, peripheral, or mixed joint involvement, often resembling seronegative spondyloarthropathy.
  • Peripheral arthritis in IBD is typically non-erosive, while axial arthritis may involve inflammatory back pain, sacroiliitis, or ankylosing spondylitis.

Purpose of the Study:

  • To review the current understanding of IBD-associated arthropathy.
  • To highlight the unclear mechanisms linking IBD and arthritis development.
  • To identify the need for further research in optimal therapeutic strategies.

Main Methods:

  • Literature review of IBD-associated arthropathy.
  • Analysis of current understanding of pathophysiology and genetic factors.
  • Evaluation of existing treatment modalities and their efficacy.

Main Results:

  • Arthritis significantly impacts morbidity and quality of life in IBD patients.
  • The precise mechanisms driving arthritis development in IBD remain largely unknown.
  • Current IBD treatments are not always sufficient for controlling associated arthritis.

Conclusions:

  • IBD-associated arthropathy requires further investigation into its underlying mechanisms.
  • There is a significant unmet need for robust clinical trials to establish optimal treatments.
  • Biologic agents show promise, but larger randomized studies are essential for validating their efficacy.