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Iron deficiency in children with early chronic kidney disease

Rossana Baracco1, Sermin Saadeh, Rudolph Valentini

  • 1Pediatric Nephrology, Children's Hospital of Michigan, 3901 Beaubien St. 4th Floor Carl's Building, Detroit, MI 48201, USA.

Pediatric Nephrology (Berlin, Germany)
|June 29, 2011
PubMed

Insights

Iron deficiency is common in children with early chronic kidney disease (CKD). Monitoring iron levels and treatment are crucial for these pediatric patients to prevent anemia.

Area of Science:

  • Pediatric Nephrology
  • Hematology

Background:

  • Iron deficiency (ID) is a known contributor to anemia in chronic kidney disease (CKD).
  • The prevalence of ID in children with early-stage CKD has not been well-documented.

Purpose of the Study:

  • To determine the frequency of iron deficiency in children with early CKD (stages 2 and 3).
  • To assess the relationship between iron deficiency, anemia, and CKD stage in pediatric patients.

Main Methods:

  • Retrospective chart review of 50 children (stages 2-3 CKD) at a pediatric CKD clinic.
  • Iron deficiency defined by low ferritin and transferrin saturation <20%; patients on iron supplements were included.
  • Analysis of iron status, anemia presence, and correlation with CKD stage and gender.

Main Results:

  • Iron deficiency was present in 42% of the pediatric CKD patients.
  • Nearly half (42.9%) of patients with ID also had anemia.
  • ID with anemia significantly increased from 4.3% in stage 2 to 29.6% in stage 3 CKD (p=0.03).
  • Females exhibited a higher frequency of ID (64.3%).

Conclusions:

  • Iron deficiency is frequent in children with early-stage chronic kidney disease.
  • Early detection and management of ID are important to prevent or treat anemia in this population.
  • Further monitoring of iron status is recommended for pediatric CKD patients.

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