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Related Concept Videos

Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...

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Related Experiment Video

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Grafting of Beads into Developing Chicken Embryo Limbs to Identify Signal Transduction Pathways Affecting Gene Expression
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CXCL14 expression during chick embryonic development.

Christopher T Gordon1, Christine Wade, Inigo Brinas

  • 1Craniofacial Development Laboratory, Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia. chris.gordon@inserm.fr

The International Journal of Developmental Biology
|June 29, 2011
PubMed
Summary
This summary is machine-generated.

This study maps the embryonic expression of CXCL14 in chick embryos, revealing novel patterns. These findings suggest CXCL14 may play a role in embryonic development, similar to CXCL12-CXCR4 signaling.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Chemokines are signaling molecules crucial for immune cell attraction.
  • The CXCL12-CXCR4 pathway is vital for non-immune cell functions during embryonic development.
  • The role of CXCL14 during embryogenesis is currently unknown.

Purpose of the Study:

  • To investigate the embryonic expression pattern of the chemokine CXCL14 in chick embryos.
  • To compare the expression of CXCL14 in chicks with its known patterns in fish and frog embryos.
  • To identify potential developmental roles for CXCL14 based on its expression sites.

Main Methods:

  • Whole-mount in situ hybridization was used to analyze CXCL14 expression patterns.
  • Expression analysis was performed across various embryonic tissues in chick embryos.
  • Comparative analysis with existing data from zebrafish and Xenopus embryos was conducted.

Main Results:

  • Chick CXCL14 exhibits a complex expression pattern during embryogenesis.
  • Expression was observed in novel sites including branchial arches, trigeminal placode/ganglion, inner ear, dorsal brain midline, somites, trunk neural tube, and limb bud.
  • Some expression domains showed conservation with fish and frog, while others were unique to the chick.

Conclusions:

  • Chick CXCL14 is expressed in diverse embryonic tissues, suggesting multifaceted developmental roles.
  • The identified expression patterns indicate potential involvement of CXCL14 in developmental events.
  • CXCL14 may participate in developmental processes similar to those regulated by the CXCL12-CXCR4 signaling pathway.