Related Experiment Video
Updated: May 31, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Characterization of new topical ketoprofen formulations prepared by drug entrapment in solid lipid matrices
Anna Argemí1, Concepción Domingo, Ana Raquel Sampaio de Sousa
1Department of Analytical Chemistry, University of Barcelona, E-08028 Barcelona, Spain.
Abstract:
This paper describes the evaluation of a new pharmaceutical formulation based on ketoprofen entrapment in a solid lipid particle (SLP) matrix. The drug-SLP samples, which were elaborated using a processing technology based on supercritical CO(2) , consisted of a model of a controlled-release system for topical applications. Some of the samples contained silanized TiO(2) as an additional ingredient to increase the interaction between drug and lipid matrix. The study of the sample features relied on reversed-phase high-performance liquid chromatography with a C(18) column and ultraviolet spectroscopic detection at 266 nm. Characterization assays comprised the determination of the overall amount of ketoprofen in the samples, the assessment of the release-permeation kinetic profiles, and the evaluation of impurities and decomposition products. The release and permeation of encapsulated ketoprofen were assayed at 32°C and pH 6.8 by using a static diffusion cell. Results showed a sustained drug delivery for at least 24 h. Besides, no degradation species were detected throughout the release-permeation processes, which indicated that the stability of the drug in the SLP system was preserved.
More Related Videos
Related Concept Videos
Bioavailability Enhancement: Drug Permeability Enhancement
Modified-Release Drug Delivery Systems: Site-Targeted
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles in drug...
Biopharmaceutics and Pharmacokinetics: Overview
Modified-Release Drug Delivery Systems: Rate-Programmed II
Factors Influencing Drug Absorption: Pharmaceutical Parameters

