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Stromal Cell Isolation From Hematopoietic Organs

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Published on: January 26, 2024

Bone marrow processing with the AMICUS™ separator system.

V Witt¹, E Beiglböck, G Fritsch

¹St. Anna Kinderspital, Vienna, Austria. volker.witt@stanna.at

Journal of Clinical Apheresis

|June 29, 2011

Summary

This summary is machine-generated.

The AMICUS™ system can process bone marrow (BM) for ABO incompatible transplantation, effectively depleting erythrocytes. While CD34+ cell collection efficiency was slightly lower, the device demonstrated safety and efficacy in this application.

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Area of Science:

Hematology
Transplantation Medicine
Medical Device Technology

Background:

ABO incompatible bone marrow transplantation (BMT) necessitates processing donated bone marrow (BM) to remove erythrocytes or reduce volume.
The AMICUS™ system, known for peripheral blood mononuclear cell collection, was evaluated for its performance in BM processing.

Purpose of the Study:

To evaluate the efficacy and safety of the AMICUS™ system for mononuclear cell (MNC) collection from BM for ABO incompatible BMT.
To compare the AMICUS™ device with the Fenwal CS3000™ plus device in terms of erythrocyte depletion and CD34+ cell yield.

Main Methods:

A retrospective analysis of 22 automated erythrocyte depletions of BM from 21 patients undergoing ABO mismatched BMT between 2005 and 2008.
Procedures were performed using either the AMICUS™ (11 procedures) or the Fenwal CS3000™ plus (11 procedures) device.

Main Results:

No significant differences were observed in donor/recipient age, ABO mismatch type, or CD34+ cell yield between the two devices.
The AMICUS™ device showed a trend towards lower CD34+ cell collection efficiency (70% ± 12 vs. 84% ± 12) and higher erythrocyte volume in the final product (9.46 ± 2.3 ml vs. 6.98 ± 3.3 ml), though not statistically significant.
No technical issues were reported, and sustained engraftment was observed in all but one patient.

Conclusions:

The AMICUS™ device is suitable for MNC collection from BM for erythrocyte depletion in allogeneic stem cell transplantation.
The device demonstrates acceptable performance for processing BM grafts in ABO incompatible BMT settings.