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Updated: May 31, 2026

Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation
Published on: September 16, 2018
[Depyrogenation in key manufacturing processes of Reduning injection]
Objective:
To investigate the effect of removing bacterial endotoxin in the key processes of Reduning injection.
Method:
The content of bacterial endotoxins was detected by kenitic-turbidimetry and the removal efficacy was studied before and after using 0.8% of activated carbon and ultrafiltration with molecular weight cut-off of 10 x 10(3).
Result:
The adsorption rate of bacterial endotoxins was 78.7% by using activated carbon, while the removal efficacy of bacterial endotoxins was 99.6% with ultrafiltration membrane at cut-off molecular weight 10 x 10(3).
Conclusion:
The key technology can effectively guarantee the safety of Reduning injection.
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