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Related Experiment Video

Updated: May 31, 2026

Elucidation of the Material Basis of Yiqi Qingjie Formula Against IgA Nephropathy Using UHPLC-Q-Orbitrap HRMS Integrated with Network Pharmacology
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Elucidation of the Material Basis of Yiqi Qingjie Formula Against IgA Nephropathy Using UHPLC-Q-Orbitrap HRMS Integrated with Network Pharmacology

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[Study on discriminating nephrotoxic components in Zexie].

Xiaoping Zhao1, Lin Lu, Yufeng Zhang

  • 1Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. zhaoxiaoping8686@sina.com

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|June 30, 2011
PubMed
Summary

Researchers identified specific compounds in Zexie that may cause kidney damage. This finding is crucial for controlling the quality and safety of this traditional herb.

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Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Toxicology

Context:

  • Zexie is a traditional herb with potential therapeutic uses.
  • Controlling the quality of herbal medicines is essential for patient safety.
  • Identifying toxic components in herbs is a critical aspect of quality control.

Purpose:

  • To identify the specific nephrotoxic components present in Zexie.
  • To establish quality control parameters for Zexie based on its toxic constituents.
  • To understand the chemical basis of Zexie's potential kidney toxicity.

Summary:

  • Preparative High-Performance Liquid Chromatography (Pre-HPLC) was used to fractionate Zexie extracts.
  • Nephrotoxicity screening was performed using LLC-PK1 cells with fluorescein diacetate (FDA) and MTT assays.

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Last Updated: May 31, 2026

Elucidation of the Material Basis of Yiqi Qingjie Formula Against IgA Nephropathy Using UHPLC-Q-Orbitrap HRMS Integrated with Network Pharmacology
08:44

Elucidation of the Material Basis of Yiqi Qingjie Formula Against IgA Nephropathy Using UHPLC-Q-Orbitrap HRMS Integrated with Network Pharmacology

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Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments
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  • Liquid Chromatography-Mass Spectrometry (LC-MS) identified alisol C, 16, 23-oxido-alisol B, and alisol O in the most toxic fraction (C13).

    • Impact:

    • This study pinpoints specific compounds responsible for Zexie's nephrotoxicity.
    • The findings provide a basis for developing quality control standards for Zexie.
    • Understanding these toxic components can guide the safe use and formulation of Zexie-based medicines.