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Updated: May 31, 2026

Genetic Incorporation of Biosynthesized L-dihydroxyphenylalanine (DOPA) and Its Application to Protein Conjugation
Published on: August 24, 2018
Synthesis and biological evaluation of a polyglutamic acid-dopamine conjugate: a new antiangiogenic agent
Cristina Fante1, Anat Eldar-Boock, Ronit Satchi-Fainaro
1Reading School of Pharmacy, University of Reading, Whiteknights, RG6 6AD, Berkshire, UK.
Abstract:
Dopamine has previously been shown to inhibit angiogenesis in vitro and in vivo, but its clinical applications in this context are severely limited by its short half-life. Here we report the synthesis of a polyglutamic acid-dopamine conjugate and show that conjugation significantly extends (from 1 to 24 h) dopamine's antiangiogenic activity in vitro and in vivo. These findings form the basis for the development of a new class of agents for the treatment of angiogenesis-dependent diseases.
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