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Related Concept Videos

Interphase00:54

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
Interphase00:56

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
Phases of Interphase
Following each period of mitosis and cytokinesis, eukaryotic cells enter interphase, during which they grow and replicate...
Interphase00:56

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
Phases of Interphase
Following each period of mitosis and cytokinesis, eukaryotic cells enter interphase, during which they grow and replicate...
Interphase00:54

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
Chromosome Structure02:40

Chromosome Structure

A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
Chromosome Structure02:40

Chromosome Structure

A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...

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Related Experiment Video

Updated: May 31, 2026

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
17:14

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization

Published on: December 10, 2012

Interphase chromosome structures of human cells.

Gaspar Banfalvi1, Gabor Nagy

  • 1Department of Microbial Biotechnology and Cell Biology, University of Debrecen, Debrecen, Hungary. bgaspar@delfin.klte.hu

DNA and Cell Biology
|June 30, 2011
PubMed
Summary

This study visualizes key stages of chromosome condensation in K562 cells, revealing distinct chromatin structures from decondensed veils to linear chromosomes. Findings support the helical coil model of chromosome formation during cell division.

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Related Experiment Videos

Last Updated: May 31, 2026

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
17:14

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization

Published on: December 10, 2012

Chromosomal Spread Preparation of Human Embryonic Stem Cells for Karyotyping
10:42

Chromosomal Spread Preparation of Human Embryonic Stem Cells for Karyotyping

Published on: September 4, 2009

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

Area of Science:

  • Cell Biology
  • Molecular Genetics
  • Chromatin Dynamics

Background:

  • Understanding chromosome condensation is crucial for cell division.
  • K562 erythroleukemia cells provide a model for studying these processes.

Purpose of the Study:

  • To identify and characterize major intermediates in chromosome condensation within K562 cells.
  • To visualize large-scale chromatin structures during interphase and chromosome formation.

Main Methods:

  • Fluorescence microscopy was employed to observe chromatin structures.
  • Reversal of permeabilization allowed visualization of interphase chromatin.

Main Results:

  • Seven major intermediates of K562 cell chromatin condensation were distinguished: chromatin veil, ribbon, funnel (earliest interphase chromosome form), body, 300 nm fiber, U/V/S-shaped chromosomes, and linear chromosomes.
  • Observations align with the helical coil model of chromosome condensation.

Conclusions:

  • The study presents a detailed linear arrangement of chromatin condensation intermediates.
  • The findings validate the helical coil model for chromosome formation in K562 cell nuclei.