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[Acyclovir-resistant herpes simplex virus].

P Aukrust1

  • 1Medisinsk avdeling, A Rikshospitalet, Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|September 10, 1990
PubMed
Summary
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Acyclovir-resistant herpes simplex virus infections are a growing concern in immunocompromised patients. Alternative antivirals like vidarabine, foscarnet, and ganciclovir are effective treatments for these resistant viral infections.

Area of Science:

  • Virology
  • Antimicrobial Resistance

Context:

  • Acyclovir-resistant herpes simplex virus (HSV) infections pose a significant clinical challenge.
  • These infections are particularly prevalent in individuals with compromised immune systems, such as those with AIDS.

Purpose:

  • To highlight the emergence of acyclovir resistance in HSV infections.
  • To discuss the primary mechanism of resistance and alternative treatment options.

Summary:

  • The most frequent cause of acyclovir resistance in HSV is the selection of viral mutants lacking thymidine kinase activity.
  • Vidarabine, foscarnet, and ganciclovir are effective therapeutic agents against acyclovir-resistant HSV.
  • Drug resistance in viral infections is an increasingly reported phenomenon across various viral agents.

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Impact:

  • This information is crucial for clinicians managing immunocompromised patients with HSV.
  • Understanding resistance mechanisms guides the selection of appropriate antiviral therapies.
  • Highlights the broader issue of antiviral drug resistance in clinical practice.