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Published on: February 15, 2016
Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives
Afsheen Arshad1, Hasnah Osman, Mark C Bagley
1School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
Abstract:
Two novel series of hydrazinyl thiazolyl coumarin derivatives have been synthesized and fully characterized by IR, (1)H NMR, (13)C NMR, elemental analysis and mass spectral data. The structures of some compounds were further confirmed by X-ray crystallography. All of these derivatives, 10a-d and 15a-h, were screened in vitro for antimicrobial activity against various bacteria species including Mycobacterium tuberculosis and Candida albicans. The compounds 10c, 10d and 15e exhibited very good activities against all of the tested microbial strains.
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