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Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
Published on: September 24, 2021
Pacemaker clinic: an opportunity to detect silent atrial fibrillation and improve antithrombotic treatment
Sandra Cabrera1, Jordi Mercé, Ramón de Castro
1Servei de Cardiologia, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain.
Insights
Atrial fibrillation (AF) is common in pacemaker patients, affecting over a third. Anticoagulant treatment is underused despite high embolism risk in these patients.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Device Technology
Background:
- Atrial fibrillation (AF) is frequently undiagnosed in pacemaker patients.
- Pacemakers are implanted for various reasons including atrioventricular block and sinoatrial node dysfunction.
Purpose of the Study:
- To evaluate the prevalence of AF in patients with pacemakers.
- To assess the appropriateness of antithrombotic treatment in this patient cohort.
Main Methods:
- Retrospective analysis of 585 patients undergoing pacemaker checks in 2008.
- Atrial activity assessed via pacemaker diagnostics and electrograms.
- Cardiologist evaluation of antithrombotic treatment appropriateness.
Main Results:
- AF was detected in 36.9% of patients during a 5.5-year monitoring period.
- Only 58.3% of patients with AF received anticoagulant therapy, despite a high mean CHADS2 score (≥2 in 77%).
- Factors associated with anticoagulant use included AF at implantation and atrioventricular synchronized pacing.
Conclusions:
- Atrial fibrillation is highly prevalent in pacemaker recipients.
- There is a significant underuse of anticoagulant therapy in this population, indicating a potential gap in stroke prevention strategies.
Aims:
The prevalence of atrial fibrillation (AF) in patients with pacemakers is high, and often passes unnoticed. Our aim was to assess the use of antithrombotic treatment in this group of patients.
Methods And Results:
All patients who came to our institution to have their pacemakers checked during the year 2008 were included in this study. The atrial activity was assessed by slowing down the paced frequency if necessary, and by the analysis of atrial electrograms in atrial-based pacemakers. The appropriateness of the antithrombotic treatment was evaluated by a cardiologist. Out of 585 patients, 216 (36.9%) displayed AF at some point during the 5.5-year monitoring period (1.5-11), although only 58 (9.9%) displayed it at the time of the implant. Of these 216, 58% were men, with an average age of 80 years (76-86 years). The pacemaker was implanted in response to an atrioventricular block (AVB) in 46.3% of the cases, sinoatrial node disorder in 24.1% of the cases, and slow AF in 25.9% of the cases. The CHADS2 score was 0 points in 4.2% (9) of the cases, 1 point in 19% (41) of the cases, and ≥ 2 points in 77% (173) of the cases. Despite this, only 58.3% of the cases received anticoagulant treatment. The existence of arrhythmia at the time of implantation [odds ratio (OR) = 4.25; 95% confidence interval (95% CI), 1.72-10.51; P = 0.002] and the implantation of a pacemaker with atrioventricular synchronization (OR = 13.23; 95% CI, 2.89-60.56; P = 0.001) were associated with the use of anticoagulant treatment in those cases with CHADS2>2.
Conclusion:
Atrial fibrillation is common in patients fitted with pacemakers. Despite the high risk of embolism, an underuse of anticoagulant treatment was observed.
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