[An analysis of the simian T-cell leukemia virus clonally integrated in baboon malignant lymphoma]

Proviral integration of a simian T-cell leukemia virus, S(H)TLV-I, highly homologous to human T-cell leukemia virus type 1 was examined in cellular DNAs isolated from lymphoid organs of lymphomatous and healthy baboons from the Sukhumi monkey colony. Most of the sick and some of healthy monkeys contained HTLV-I-related sequences in their chromosomal DNAs. Judging from the integration site of the provirus genome, S(H)TLV-I-infected cells had selective preferences and proliferated monoclonally.