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Related Experiment Video

Updated: May 31, 2026

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

Higher Order Spike Synchrony in Prefrontal Cortex during Visual Memory.

Gordon Pipa1, Matthias H J Munk

  • 1Department of Neurophysiology, Max-Planck-Institute for Brain Research Frankfurt/Main, Germany.

Frontiers in Computational Neuroscience
|June 30, 2011
PubMed
Summary
This summary is machine-generated.

Neurons in the prefrontal cortex synchronize their firing with millisecond precision, especially during memory tasks. This precise neural synchrony is linked to behavioral performance and visual memory.

Keywords:
behavioral performancejoint-spike eventsjoint-spike patternsmulti-unit activityprimate prefrontal cortexspike synchronystimulus codingvisual short-term memory

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Detecting Pre-Stimulus Source-Level Effects on Object Perception with Magnetoencephalography
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Related Experiment Videos

Last Updated: May 31, 2026

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

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Published on: February 25, 2022

Detecting Pre-Stimulus Source-Level Effects on Object Perception with Magnetoencephalography
09:25

Detecting Pre-Stimulus Source-Level Effects on Object Perception with Magnetoencephalography

Published on: July 26, 2019

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Computational Neuroscience

Background:

  • Precise temporal synchrony of neuronal firing is a proposed mechanism for signal integration and plasticity induction in the neocortex.
  • The prefrontal cortex (PFC) is crucial for memory and executive functions, receiving input from multiple visual pathways.
  • Neuronal synchrony is hypothesized to increase during stimulus processing and memory-related plasticity in the PFC.

Purpose of the Study:

  • To investigate the precise temporal synchrony of neuronal firing in the ventral prefrontal cortex.
  • To determine if neuronal synchrony is modulated by behavioral performance and specific visual stimuli during memory tasks.
  • To examine the spatial extent and performance dependency of synchronous discharges.

Main Methods:

  • Simultaneous multi-unit recordings were performed in the ventral prefrontal cortex.
  • Analysis focused on precisely synchronized discharges (3 ms) across multiple recording sites.
  • Investigated the relationship between spike synchronization frequency, behavioral performance, and visual stimuli during memory recall.

Main Results:

  • Neurons in the ventral prefrontal cortex exhibit 3 ms precise synchronous discharges across sites separated by at least 500 μm.
  • The frequency of synchronous firing is modulated by behavioral performance.
  • Synchronous firing patterns are specific to memorized visual stimuli, with larger groups of sites showing performance-dependent modulation during memory recall.

Conclusions:

  • Precise spike synchrony is a key feature of neuronal communication in the ventral prefrontal cortex during memory tasks.
  • Neuronal synchrony in the PFC is dynamically regulated by behavioral performance and the nature of the memorized information.
  • These findings support the role of precise temporal coding in memory and plasticity within the prefrontal cortex.