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Sickle cell disease and venous thromboembolism
1Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Summary
Sickle cell disease (SCD) patients face increased risks of blood clots due to hypercoagulability. This review examines genetic factors and hemostasis changes contributing to these thromboembolic events, particularly in Mediterranean populations.
Area of Science:
- Hematology
- Genetics
- Vascular Medicine
Background:
- Sickle cell disease (SCD) involves chronic hemolytic anemia and vasoocclusion.
- SCD patients exhibit a hypercoagulable state, increasing thromboembolic complication risks.
- Understanding genetic factors and hemostasis alterations is crucial for managing SCD complications.
Purpose of the Study:
- To review literature on thromboembolic events in SCD patients.
- To identify genetic risk factors associated with these events, focusing on Mediterranean studies.
- To explore the pathogenesis of hypercoagulability and hemostasis system changes in SCD.
Main Methods:
- Literature review of studies on SCD, thromboembolism, and genetic factors.
- Focus on research from Mediterranean countries.
- Analysis of hemostasis system components and hypercoagulability mechanisms.
Main Results:
- SCD is linked to chronic hypercoagulability and elevated risk of thromboembolic events.
- Genetic variants and hemostasis system alterations contribute to thrombotic risk in SCD.
- Mediterranean studies highlight specific genetic factors and their impact.
Conclusions:
- Thromboembolic events are a significant concern in sickle cell disease.
- Genetic risk factors and hemostasis dysregulation play key roles in SCD thrombotic complications.
- Further research, especially from diverse regions like the Mediterranean, is needed to refine management strategies.
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