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Sickle cell disease and venous thromboembolism

Zohreh Rahimi1, Abbas Parsian

  • 1Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Mediterranean Journal of Hematology and Infectious Diseases
|June 30, 2011
PubMed

Hemoglobin S in homozygous state or in combination with one of the structural variants of Hb D-Punjab, Hb O-Arab, Hb C or β-thalassemia mutation results in sickle cell disease (SCD) that is characterized by chronic hemolytic anemia and tissue injury secondary to vasooclusion. A chronic hypercoagulable state in SCD has been established with the increased risk of thromboembolic complications in these patients. The goal of present review is to survey of the literature related to thromboembolic events and genetic risk factors involved in the manifestation of these events in SCD patients with focus on studies from Mediterranean countries. Also, this review covers the pathogenesis of hypercoagulability and alteration in the components of hemostasis system.

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