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Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats
S H Shukla1, A K Saluja, S S Pandya
1Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 121, India.
Aim:
In the present study, the immunomodulatory effects of roots of Gmelina arborea Linn. were investigated
Materials And Methods:
Methanolic extract of G. arborea Linn. (MEGA) and its ethyl acetate fraction (EAFME) were used for evaluating the pharmacological activity. The modulating effect was evaluated on humoral and cell-mediated immune response using animal models like cyclophosphamide-induced myelosuppression, delayed-type hypersensitivity (DTH) response, and humoral antibody (HA) titre
Results:
Both test extracts produced significant increase in HA titre, DTH response, and levels of total white blood cell count
Conclusion:
This drug is found to be a potential immunostimulant.
