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Confronting cisternae presenting as intracytoplasmic inclusions in monocytes
C K Berkley1, J D Parkin, L C Peterson
1Hennepin County Medical Center, Minneapolis, Minnesota 55415.
American Journal of Clinical Pathology
|October 1, 1990
Summary
Renal failure patients may exhibit unique leukocyte inclusions. These gray-blue cytoplasmic structures, identified as confronting cisternae, are a novel finding distinct from Döhle bodies.
Area of Science:
- Hematology
- Pathology
- Nephrology
Background:
- Renal failure can manifest with various hematologic abnormalities.
- Intracytoplasmic inclusions in leukocytes are diagnostically significant.
Observation:
- Peripheral blood analysis revealed small, gray-blue intracytoplasmic inclusions in monocytes and neutrophils.
- These inclusions were observed in a patient diagnosed with renal failure.
Findings:
- Ultrastructural examination identified the inclusions as confronting cisternae within the leukocyte cytoplasm.
- This represents a previously undescribed morphologic feature in leukocytes.
Implications:
- The findings highlight a new cellular characteristic in renal failure.
- Distinguishing these inclusions from Döhle bodies is crucial for accurate diagnosis.
- This discovery may refine diagnostic criteria for leukocyte abnormalities.