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Confronting cisternae presenting as intracytoplasmic inclusions in monocytes
C K Berkley1, J D Parkin, L C Peterson
1Hennepin County Medical Center, Minneapolis, Minnesota 55415.
Abstract:
Small gray-blue intracytoplasmic inclusions were noted in the peripheral monocytes and neutrophils from a patient with renal failure. Ultrastructural analysis revealed confronting cisternae within the cytoplasm. The authors submit a case report to introduce a previously undescribed morphologic feature of leukocytes that may be mistaken at the light microscopic level for Döhle bodies or other inclusions.
Insights
Renal failure patients may exhibit unique leukocyte inclusions. These gray-blue cytoplasmic structures, identified as confronting cisternae, are a novel finding distinct from Döhle bodies.
Area of Science:
- Hematology
- Pathology
- Nephrology
Background:
- Renal failure can manifest with various hematologic abnormalities.
- Intracytoplasmic inclusions in leukocytes are diagnostically significant.
Observation:
- Peripheral blood analysis revealed small, gray-blue intracytoplasmic inclusions in monocytes and neutrophils.
- These inclusions were observed in a patient diagnosed with renal failure.
Findings:
- Ultrastructural examination identified the inclusions as confronting cisternae within the leukocyte cytoplasm.
- This represents a previously undescribed morphologic feature in leukocytes.
Implications:
- The findings highlight a new cellular characteristic in renal failure.
- Distinguishing these inclusions from Döhle bodies is crucial for accurate diagnosis.
- This discovery may refine diagnostic criteria for leukocyte abnormalities.