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Updated: May 31, 2026

Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry
Published on: October 24, 2018
Metall(prote)omic studies by capillary electrophoresis using separation capillary as an in-line reactor
Andrei R Timerbaev1, Lidia S Foteeva, Katarzyna Pawlak
1Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Kosygin St. 19, 119991, Moscow, Russia. andrei.timerbaev@univie.ac.at
Abstract:
This perspective article highlights the potential of capillary electrophoresis (CE) in in-line monitoring of biomolecular reactions related to in vivo transformations of metal species. In such scrutinizing, the capillary is regarded as a nanolitre-volume reactor in which electrical field-driven reactants are mixed to produce a response that enables in situ following-up and characterization of non-covalent molecular interactions. The concept of a CE reactor has been extended here to the investigation of processes that are responsible for the formation and decomposition of metal-bioligand species under simulated physiological conditions.
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