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Related Experiment Videos

Oral estrogens decrease bleeding time and improve clinical bleeding in patients with renal failure.

D Shemin1, M Elnour, B Amarantes

  • 1Department of Medicine, Rhode Island Hospital, Providence 02903.

The American Journal of Medicine
|October 1, 1990
PubMed
Summary
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Oral conjugated estrogens effectively treat bleeding issues in patients with chronic renal failure. This study shows Premarin significantly reduces prolonged bleeding times and stops bleeding in these patients.

Area of Science:

  • Nephrology
  • Hematology
  • Pharmacology

Background:

  • Prolonged bleeding time is a common complication in patients with renal failure, linked to platelet dysfunction and clinical bleeding.
  • Parenteral estrogens have demonstrated efficacy in shortening bleeding times in chronic renal failure patients, but their mechanism remains unclear.

Purpose of the Study:

  • To evaluate the effectiveness of orally administered conjugated estrogens in managing prolonged bleeding times in patients with renal failure.

Main Methods:

  • A study involving four patients with renal failure and bleeding issues who received 50 mg of oral conjugated estrogen (Premarin) daily.
  • A subsequent randomized, placebo-controlled trial with ten dialysis patients, where five received 50 mg of Premarin daily and five received a placebo.

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Main Results:

  • In the initial group, bleeding time normalized in two patients and decreased by over 50% in another; bleeding ceased within two days for all.
  • In the randomized trial, all five patients treated with Premarin experienced normalized or significantly reduced bleeding times within 7.0 +/- 4.2 days.
  • No normalization of bleeding time was observed in the placebo group, and no adverse effects were reported with Premarin therapy.

Conclusions:

  • Orally administered conjugated estrogens are an effective treatment for improving bleeding tendency in individuals with chronic renal failure.
  • Conjugated estrogens offer a viable therapeutic option for managing bleeding complications associated with renal failure.