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Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Transport Across the Golgi01:26

Transport Across the Golgi

While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...

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Related Experiment Video

Updated: May 31, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Mast cell progenitor trafficking and maturation.

Jenny Hallgren1, Michael F Gurish

  • 1Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

Advances in Experimental Medicine and Biology
|June 30, 2011
PubMed
Summary

Mast cell progenitor migration to tissues is tissue-specific. Allergic inflammation in the lung uniquely recruits mast cell progenitors via specific molecular pathways.

Area of Science:

  • Immunology
  • Cell Biology
  • Hematopoiesis

Background:

  • Mast cells originate from hematopoietic progenitors in the bone marrow and spleen.
  • Committed mast cell progenitors are released into circulation for tissue homing.
  • Tissue-specific migration mechanisms guide progenitor trafficking.

Purpose of the Study:

  • To elucidate the molecular mechanisms governing mast cell progenitor migration to different tissues.
  • To investigate the distinct pathways involved in basal versus inflammation-induced mast cell progenitor recruitment.

Main Methods:

  • Analysis of gene and protein expression (integrins, chemokine receptors, adhesion molecules) in mast cell progenitors.
  • Investigation of endothelial cell interactions and dendritic cell involvement.

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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
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Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Related Experiment Videos

Last Updated: May 31, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

  • Comparison of migratory requirements in the intestine versus the lung under basal and inflammatory conditions.

    • Main Results:

    • Basal intestinal trafficking requires α4β7 integrin, CXCR2, MAdCAM-1, VCAM-1, and T-bet-expressing dendritic cells.
    • These factors are not essential for basal lung trafficking.
    • Allergic lung inflammation induces recruitment of mast cell progenitors expressing α4β7 and α4β1 integrins, requiring VCAM-1, CXCR2, CCR2, and CCL2 pathways.

    Conclusions:

    • Mast cell progenitor migration is tightly regulated in a tissue-specific manner.
    • Distinct molecular pathways govern basal homing versus inflammation-driven recruitment.
    • Understanding these pathways is crucial for controlling mast cell populations in inflammatory diseases.