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Related Concept Videos

Inflammation01:38

Inflammation

Overview
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Related Experiment Video

Updated: May 31, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Mast cells and immunoregulation/immunomodulation.

Mindy Tsai1, Michele Grimbaldeston, Stephen J Galli

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

Advances in Experimental Medicine and Biology
|June 30, 2011
PubMed
Summary
This summary is machine-generated.

Mast cells are key immune cells interacting with pathogens and toxins. Mouse models reveal their complex roles in modulating immune responses, acting as either beneficial defenders or contributors to disease.

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Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
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Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Related Experiment Videos

Last Updated: May 31, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mast cells are crucial immune cells that interact with environmental antigens, pathogens, and toxins.
  • They play a significant role in both innate and adaptive immune responses, with potential alterations in their function and distribution.
  • Beyond their established role in allergic reactions, mast cells can be activated by diverse signals, including pathogen-derived molecules.

Purpose of the Study:

  • To describe mouse models utilized for analyzing mast cell function in vivo.
  • To illustrate how these models have identified the immunomodulatory roles of mast cells in immune responses.
  • To explore the potential of mast cell functions, products, and receptors in regulating immune responses.

Main Methods:

  • Utilized established mouse models for in vivo mast cell functional analysis.
  • Investigated mast cell interactions within the context of innate and adaptive immune responses.
  • Examined mast cell products, surface receptors, and their regulatory activities.

Main Results:

  • Mouse models have been instrumental in dissecting the in vivo functions of mast cells.
  • Identified both positive and negative immunomodulatory roles for mast cells in various immune responses.
  • Demonstrated that mast cells can either enhance host defense or contribute to disease pathogenesis.

Conclusions:

  • Mast cells possess multifaceted immunoregulatory capabilities.
  • Their functions can be harnessed to either bolster host defense mechanisms or exacerbate disease conditions.
  • Further research into mast cell biology is essential for understanding and manipulating immune responses.