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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Inflammation01:38

Inflammation

Overview
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...

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Related Experiment Video

Updated: May 31, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Mast cells in lung inflammation.

Elena P Moiseeva1, Peter Bradding

  • 1Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK.

Advances in Experimental Medicine and Biology
|June 30, 2011
PubMed
Summary
This summary is machine-generated.

Mast cells are crucial in lung health and disease, mediating inflammation and repair. Therapies targeting their function could treat severe lung conditions like asthma.

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Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung
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Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung

Published on: November 16, 2021

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Related Experiment Videos

Last Updated: May 31, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung
09:57

Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung

Published on: November 16, 2021

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Area of Science:

  • Immunology
  • Pulmonology
  • Cell Biology

Background:

  • Mast cells are key immune cells in the lungs, involved in host defense and tissue repair.
  • Their activation initiates inflammatory responses to various stimuli, impacting lung health.
  • Dysregulated mast cell activity contributes to lung diseases such as asthma and interstitial lung disease.

Purpose of the Study:

  • To investigate the multifaceted role of mast cells in lung physiology and pathology.
  • To explore the potential of targeting mast cell functions for therapeutic interventions.
  • To understand mast cell involvement in host immunity against bacterial infections and non-small cell lung cancer.

Main Methods:

  • Review of current literature on mast cell biology in the context of lung diseases.
  • Analysis of mast cell mediator release in response to diverse stimuli.
  • Examination of mast cell contributions to inflammatory and repair processes in the lung.

Main Results:

  • Mast cells are central to initiating inflammation and repair in the lung.
  • Sustained mediator release by mast cells exacerbates lung disease pathophysiology.
  • Mast cells play a role in immunity against bacterial infections and potentially in non-small cell lung cancer.

Conclusions:

  • Modulating mast cell activity is a promising therapeutic strategy for lung diseases.
  • Targeting adverse mast cell functions may offer novel treatments for life-threatening respiratory conditions.
  • Further research into chronic in vivo mast cell modulation is warranted for clinical application.