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Antimicrobial resistant pattern of Escherichia coli strains isolated from pediatric patients in Jordan

Mohammad Alshara1

  • 1Department of Pharmacology, Irbid National University, Irbid, Jordan. alshara_70@yahoo.com

Acta Medica Iranica
|June 30, 2011
PubMed

Insights

This study analyzed antimicrobial resistance in Escherichia coli (E. coli) from Jordanian children. High resistance to ampicillin and amoxicillin-clavulanic acid was found, while amikacin showed 100% effectiveness.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pediatrics

Background:

  • Escherichia coli (E. coli) is a common cause of pediatric infections.
  • Understanding antimicrobial resistance patterns is crucial for effective treatment.
  • Data on E. coli resistance in Jordanian pediatric populations is limited.

Purpose of the Study:

  • To investigate the antimicrobial resistance patterns of E. coli strains.
  • To determine the susceptibility of E. coli to various antimicrobial agents.
  • To inform treatment strategies for pediatric E. coli infections in Jordan.

Main Methods:

  • Isolation and identification of E. coli from clinical specimens of pediatric patients.
  • Antimicrobial susceptibility testing using various drugs.
  • Data collection over a 12-month period (January-December 2008).

Main Results:

  • A total of 444 E. coli strains were analyzed.
  • High resistance rates were observed for ampicillin (84%), amoxicillin-clavulanic acid (74.3%), and cotrimoxazole (71%).
  • Amikacin demonstrated 100% susceptibility, followed by Cefotaxime (11%) and Ceftriaxone (11.7%).

Conclusions:

  • Ampicillin, amoxicillin-clavulanic acid, and cotrimoxazole are largely ineffective against pediatric E. coli in Jordan.
  • Amikacin is a highly effective treatment option.
  • Third-generation cephalosporins and fluoroquinolones show good susceptibility rates.

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