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New clinical concepts after the ONTARGET trial

Luis M Ruilope1, Julian Segura, Jose L Zamorano

  • 1Hypertension Unit, Hospital 12 de Octubre, Avda de Cordoba, s/n 28041, Madrid, Spain. ruilope@ad-hocbox.com

Expert Review of Cardiovascular Therapy
|July 1, 2011
PubMed

Insights

The ONTARGET trial

Area of Science:

  • Cardiology
  • Pharmacology
  • Nephrology

Background:

  • The Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial (ONTARGET) investigated cardiovascular outcomes.
  • Established cardiovascular disease patients were analyzed for treatment effects.

Purpose of the Study:

  • To analyze the ONTARGET study's findings on blood pressure control targets in cardiovascular patients.
  • To clarify the renal aspects and dual blockade of the renin-angiotensin-aldosterone system (RAAS) with telmisartan and ramipril.
  • To determine the role of statins in the study's outcomes.

Main Methods:

  • Review and commentary on the ONTARGET study data.
  • Analysis of blood pressure control, renal effects, and RAAS blockade.
  • Evaluation of statin therapy's impact on patient outcomes.

Main Results:

  • The study requires further analysis regarding optimal blood pressure targets for cardiovascular patients.
  • Renal aspects and concerns over dual RAAS blockade by telmisartan and ramipril need clarification.
  • High statin use at study's end likely contributed to residual risk reduction.

Conclusions:

  • Further investigation into blood pressure targets and RAAS blockade is warranted.
  • The role of statins in mitigating residual cardiovascular risk in the ONTARGET population is significant.
  • ONTARGET findings highlight the complex interplay of therapies in cardiovascular disease management.

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