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Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
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The novel platelet activation receptor CLEC-2.

Katsue Suzuki-Inoue1, Osamu Inoue, Yukio Ozaki

  • 1Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan. katsuei@yamanashi.ac.jp

Platelets
|July 1, 2011
PubMed
Summary

The c-type lectin-like receptor 2 (CLEC-2) is a platelet surface receptor. It binds snake venom rhodocytin, activating platelet aggregation and influencing various physiological and pathological roles.

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Area of Science:

  • Immunology
  • Hematology
  • Molecular Biology

Background:

  • C-type lectin-like receptor 2 (CLEC-2) was initially identified through bioinformatics.
  • Its function and ligands remained unknown for several years post-discovery.

Purpose of the Study:

  • To elucidate the structure, distribution, signal transduction, and functions of CLEC-2.
  • To detail the roles of CLEC-2 in physiological and pathological processes.

Main Methods:

  • Bioinformatic screening for receptor identification.
  • Functional assays demonstrating platelet aggregation.
  • Investigation of CLEC-2 expression and signaling pathways.

Main Results:

  • CLEC-2 is expressed on platelet surfaces.
  • Rhodocytin from snake venom acts as a potent CLEC-2 ligand, stimulating platelet aggregation.
  • Subsequent research has clarified endogenous/exogenous ligands and physiological/pathological roles.

Conclusions:

  • CLEC-2 plays a significant role in platelet function and immune responses.
  • Understanding CLEC-2's mechanisms provides insights into hemostasis and thrombosis.
  • Further research continues to uncover the multifaceted roles of CLEC-2.