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Published on: June 5, 2019
Platelet expression of CD62P in hypotrophic newborns
Alicja Wasiluk1, Maria Mantur, Halina Kemona
1Department of Neonatology, Medical University of Bialystok, Poland. awasiluk@umwb.edu.pl
Background:
Hypotrophic newborns demonstrate a reduced blood platelet count and therefore may have haemostasis disorders. The antigen density of CD62P on the surface of platelets may indicate the activation of blood platelets.
Materials And Methods:
We have studied 31 hypotrophic newborns, and have divided these into two groups: weighing less than the 5th centile and between the 5th and 10th centiles. The antigen density of CD62P was calculated according to the procedure recommended by DAKO QIFIKIT.
Results:
Hypotrophic newborns exhibited a median 22 000 of CD62P per platelet. There is a distinct gender difference (female median 29 768, male median 19 044 of CD62P per platelet, p = 0.001). Newborns below the 5th centile demonstrated a median 30 000 of CD62P per platelet, whereas between the 5th and 10th centiles - a median 18 700. A negative correlation (R = -0.53, p = 0.002) was found between the antigen density of CD62P and birth weight.
Conclusion:
Hypotrophy affects the expression of CD62P. There is a negative correlation between the antigen density of CD62P and birth weight.
