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A novel 8.O.6'-neolignan from Taxillus theifer
Lie-Chwen Lin1, Tung-Hu Tsai, Shao-Chieh Su
1National Research Institute of Chinese Medicine , Taipei 112 , Taiwan. lclin@nricm.edu.tw
Abstract:
A new 8.O.6'-neolignan, threo-(7R, 8R)-7-acetoxy-3',4'-dimethoxy-3,4-dimethoxy-Δ-(8')-8.O.6'-neolignan (1) along with two known lignans (2) and (3), was isolated from the leaves and stems of Taxillus theifer. Structural elucidation was carried out by 1-D and 2-D-NMR spectroscopic methods, and the absolute configurations of C-7 and C-8 in 1 were determined on the basis of circular dichroism. Compound 2 is threo-7-acetoxy-3'-methoxy-3,4-dimethoxy-Δ-(7')-8.O.4'-neolignan obtained from a natural source for the first time, previously derived from a synthesis study of 8,4'-oxyneolignans.
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