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Cananginones A–I, linear acetogenins from the stem bark of Miliusa velutina [corrected]
Nikhom Wongsa1, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul
1Natural Products Research Unit, Department of Chemistry, Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Abstract:
Nine linear C23 and C21 acetogenins, named cananginones A-I (1-9), were isolated from stem bark of Miliusa velutina [corrected] . Their structures were established by spectroscopic methods. These compounds showed cytotoxicity against three cancer cell lines (KB, MCF7 and NCI-H187) with IC₅₀ values in the range 16.6-129.7 μM. Only 5 showed weak antimalarial activity against Plasmodium falciparum. In addition, 8 and 9 exhibited weak antifungal activity against Candida albicans.