Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glomerular Filtration

Glomerular Filtration

The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.

Renal Corpuscle

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...

Diabetic Nephropathy

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

Filtration and Urine Formation

Filtration and Urine Formation

The function of the kidneys is to filter, reabsorb, secrete, and excrete. Every day the kidneys filter nearly 180 liters of blood, initially removing water and solutes but ultimately returning nearly all filtrates into circulation with the help of osmoregulatory hormones. This process removes wastes and toxins but is also crucial to maintain water and electrolyte levels. Most of these functions are performed by the tiny but numerous nephrons contained within the kidneys.

Dialysis

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A new brake on podocyte injury: ATOH8 meets TGF-β.

American journal of physiology. Renal physiology·2026

Same author

Discovery and Cryo-EM-Guided Development of a Neuropilin-2-Binding Aptamer for Receptor Antagonism.

Journal of the American Chemical Society·2026

Same author

High-throughput, organ-scale 3D tubule tracking using TubuleMAP.

bioRxiv : the preprint server for biology·2026

Same author

A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease.

Kidney international·2026

Same author

A single cell atlas of mouse podocytes upon injury identifies kidney zone-dependent responses.

bioRxiv : the preprint server for biology·2026

Same author

SPATIALLY PATTERNED PODOCYTE STATE TRANSITIONS COORDINATE AGING OF THE GLOMERULUS.

bioRxiv : the preprint server for biology·2026

Same journal

Approach to Hyperkalemia: The Role of Diet and Pharmacological Therapies.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026

Same journal

High Protein Diets: What to Tell Our Patients.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026

Same journal

Progressive Kidney Dysfunction and Ocular Clues: A Quiz.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026

Same journal

Influence of Lactate Dehydrogenase on the Measurement of Blood Bicarbonate.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026

Same journal

Urinary CXCL9 and CXCL10, Interstitial Inflammation and Disease Activity Over Time in Acute Interstitial Nephritis.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026

Same journal

Hemophagocytic Lymphohistiocytosis and Fibroblast Growth Factor 23 (FGF23)-Induced Hypophosphatemia.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 31, 2026

Generation of Patient-Derived Podocytes from Skin Biopsies

Generation of Patient-Derived Podocytes from Skin Biopsies

Published on: May 26, 2023

Podocyte biology for the bedside.

J Ashley Jefferson¹, Charles E Alpers, Stuart J Shankland

¹Division of Nephrology, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA. jjefferson@nephrology.washington.edu

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation

|July 1, 2011

Summary

This summary is machine-generated.

Recent advances in podocyte biology have transformed understanding of kidney disease and proteinuria. This review highlights findings and therapeutic implications for podocyte diseases.

More Related Videos

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions

Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions

Published on: July 2, 2020

Related Experiment Videos

Last Updated: May 31, 2026

Generation of Patient-Derived Podocytes from Skin Biopsies

Generation of Patient-Derived Podocytes from Skin Biopsies

Published on: May 26, 2023

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions

Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions

Published on: July 2, 2020

Area of Science:

Nephrology
Cell Biology
Glomerular Diseases

Background:

Podocyte biology has seen significant advancements.
Understanding of proteinuria and glomerular disease has evolved.
Progressive kidney disease research is rapidly advancing.

Observation:

The field of podocyte biology has experienced explosive growth.
Landmark findings have reshaped views on kidney pathophysiology.
Recent advances offer new insights into disease mechanisms.

Findings:

Podocyte research has yielded crucial insights into kidney disease.
New discoveries illuminate the role of podocytes in proteinuria.
The review focuses on recent breakthroughs in podocyte biology.

Implications:

Therapeutic strategies for podocyte diseases are emerging.
Translating podocyte biology into effective treatments is a key goal.
Advances offer hope for managing progressive kidney disease.