Related Experiment Video

Updated: May 31, 2026

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

Acute kidney injury on ventilator initiation day independently predicts prolonged mechanical ventilation in intensive

Sheng-Wei Pan1, Hsin-Kuo Kao, Te-Cheng Lien

  • 1Department of Respiratory Therapy, Taipei Veterans General Hospital, Taipei, Taiwan.

Journal of Critical Care
|July 1, 2011
PubMed
Abstract

Insights

Acute kidney injury (AKI) on mechanical ventilation (MV) initiation day predicts prolonged mechanical ventilation (PMV) of over 21 days. Early identification of AKI can help clinicians manage intensive care unit (ICU) patients at risk for PMV.

Area of Science:

  • Critical Care Medicine
  • Nephrology
  • Respiratory Medicine

Background:

  • Prolonged mechanical ventilation (PMV) is a significant concern in intensive care unit (ICU) settings.
  • Identifying predictors for PMV is crucial for optimizing patient management and resource allocation.

Purpose of the Study:

  • To identify predictors of prolonged mechanical ventilation (PMV) exceeding 21 days in ICU patients.
  • To investigate the role of acute kidney injury (AKI) as a predictor for PMV.

Main Methods:

  • A retrospective observational study was conducted in a respiratory ICU.
  • Data from 154 patients were analyzed, focusing on the occurrence of PMV and the definition of AKI based on serum creatinine levels.
  • Multivariate regression analysis was used to determine independent risk factors.

Main Results:

  • Of 154 patients, 41 (26.6%) experienced PMV.
  • Patients with PMV had higher APACHE II scores, lower albumin, and more AKI at MV initiation.
  • Independent predictors for PMV included AKI at MV initiation (OR, 5.630), longer MV duration before readiness for weaning (DRW) (OR, 1.289), and higher rapid shallow breathing index on DRW (OR, 1.012).

Conclusions:

  • Acute kidney injury (AKI) on the day of mechanical ventilation (MV) initiation is an independent risk factor for prolonged mechanical ventilation (PMV) exceeding 21 days.
  • These findings can assist clinicians in early risk stratification and management of ICU patients requiring mechanical support.

More Related Videos

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats08:22

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats

Published on: September 19, 2025

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury07:02

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Published on: February 10, 2026

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...