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Related Experiment Video

Updated: May 31, 2026

Measuring Psoriasis Severity at Home

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Psoriatic arthritis: from a dermatological perspective.

Toshiyuki Yamamoto¹

¹Department of Dermatology, Fukushima Medical University, Fukushima, Japan. toyamade@fmu.ac.jp

European Journal of Dermatology : EJD

|July 1, 2011

Summary

Psoriatic arthritis (PsA) is a chronic inflammatory condition linked to psoriasis. Early diagnosis by dermatologists is key, as skin lesions often appear before joint symptoms in psoriatic arthritis.

Area of Science:

Rheumatology and Dermatology
Immunoinflammatory diseases

Background:

Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy associated with psoriasis, classified among seronegative spondyloarthropathies.
Cutaneous psoriasis often precedes joint manifestations, positioning dermatologists to detect PsA early.
PsA exhibits unique features like enthesopathy, dactylitis, and abnormal bone remodeling.

Purpose of the Study:

To review current understanding of psoriatic arthritis pathogenesis from a dermatological viewpoint.
To highlight the role of dermatologists in early psoriatic arthritis diagnosis.
To discuss genetic, environmental, and immunological factors in PsA development.

Main Methods:

Review of existing literature on psoriatic arthritis.
Analysis of clinical presentation and unique characteristics of PsA.

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Last Updated: May 31, 2026

Measuring Psoriasis Severity at Home

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Examination of immunological pathways, including the IL-23/Th17 axis.

Main Results:

PsA presents clinically in various forms: asymmetric oligoarticular, symmetric polyarthritis, distal interphalanges predominant, arthritis mutilans, and spondylitis.
Physical stress can trigger inflammation via the 'deep Koebner' phenomenon, leading to peripheral arthritis.
Activated T-cells and macrophages are implicated in the inflammatory and destructive processes in both skin and joints.

Conclusions:

The IL-23/Th17 axis is a significant factor in psoriatic arthritis and psoriasis pathogenesis.
Targeting therapies have underscored the critical role of specific cytokines.
A dermatological perspective is crucial for understanding and managing psoriatic arthritis.