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Updated: May 31, 2026

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
Published on: January 31, 2020
Preexposure prophylaxis and timed intercourse for HIV-discordant couples willing to conceive a child
Pietro L Vernazza1, Irma Graf, Ulrike Sonnenberg-Schwan
1Division of Infectious Diseases, Kantonsspital St Gallen, Switzerland. Pietro.Vernazza@kssg.ch
Abstract:
Many HIV-discordant couples express a strong wish to conceive a child. Insemination with processed semen is offered to these couples in many countries. Given the very low level of transmission risk during fully suppressive antiretroviral therapy, we offered timed intercourse combined with preexposure prophylaxis to further reduce the transmission risk. In 53 cases, natural conception was attempted using the proposed method. Pregnancy rates were high and reached a plateau of 75% after six cycles. Advanced age in the female partner was a predictor for infertility in these couples.
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