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Quantitative analysis of SLC34A2 expression in different types of ovarian tumors
M Shyian1, V Gryshkova, O Kostianets
1Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine. m.a.shyyan@gmail.com
Aim:
The main purpose of this study was to estimate the SLC34A2 gene expression in normal ovary and different types of ovarian tumors.
Methods:
We have investigated SLC34A2 gene expression level in papillary serous, endometrioid, unspecified adenocarcinomas, benign tumors, and normal ovarian tissues using real-time PCR analysis. Differences in gene expression were calculated as fold changes in gene expression in ovarian carcinomas and benign tumors compared to normal ovary.
Results:
We have found that SLC34A2 gene was highly expressed in well-differentiated endometrioid and papillary serous ovarian carcinomas compared to low-differentiated endometrioid carcinomas, benign serous cystoadenomas and normal ovary. Analysis of SLC34A2 gene expression according to tumor differentiation level (poor- and well-differentiated) showed that SLC34A2 is up-regulated in well differentiated tumors.
Conclusion:
Upregulation of SLC34A2 gene expression in well-differentiated tumors may reflect cell differentiation processes during ovarian cancerogenesis and could serve as potential marker for ovarian cancer diagnosis and prognosis.
