Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Toxicity: Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

Drug toxicity: Idiosyncratic Reactions

Drug toxicity: Idiosyncratic Reactions

Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...

Hypersensitivity Reactions: Immune-Complex Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

Hypersensitivity Reactions: Cytolytic Reactions

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...

Drugs for Treatment of Ulcerative Colitis in IBD

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fixed Drug Eruption Inversus Associated With Meloxicam.

American journal of therapeutics·2026

Same author

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Associated with Multiple Drug Hypersensitivity Confirmed by Skin Testing.

Hospital pharmacy·2026

Same author

Impact of Onychomycosis on Quality of Life: A Cross-Sectional Study Using the Dermatology Life Quality Index.

Skin appendage disorders·2026

Same author

A novel method for rapid determination of risperidone in human plasma using Reversed-Phase Liquid Chromatography with Ultra-Violet detection.

La Tunisie medicale·2026

Same author

Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome Induced by Abiraterone: Evidence From a Positive Rechallenge.

American journal of therapeutics·2026

Same author

A Case of Acute Pancreatitis Related to Therapeutic Dosing With Colchicine and Review of the Literature.

American journal of therapeutics·2025

Search research articles

Related Experiment Videos

Acetaminophen-induced cellulitis-like fixed drug eruption.

Neila Fathallah¹, Chaker Ben Salem, Raoudha Slim

¹Department of Clinical Pharmacology, Faculty of Medicine of Sousse, Sousse, Tunisia.

Indian Journal of Dermatology

|July 1, 2011

Summary

Acetaminophen can cause severe skin reactions like fixed drug eruption, even in elderly patients. Prompt drug withdrawal is crucial for managing these rare but serious adverse effects.

Keywords:

Acetaminophen cellulitis generalized bullous fixed drug eruption

Related Experiment Videos

Area of Science:

Dermatology
Pharmacology

Background:

Acetaminophen is a common analgesic with rare but severe adverse reactions.
Fixed drug eruption (FDE) is a type of adverse drug reaction characterized by recurrent skin lesions upon re-exposure to the causative agent.

Purpose of the Study:

To report a case of generalized bullous fixed drug eruption (GBFDE) induced by acetaminophen.
To highlight the potential for acetaminophen to cause FDE and its varied clinical presentations.

Main Methods:

A case study of an 89-year-old male patient presenting with a progressive skin eruption after acetaminophen ingestion.
Clinical observation, diagnostic evaluation, and assessment of drug causality using the Naranjo probability scale.

Main Results:

The patient developed an edematous, erythematous plaque that evolved into flaccid vesicles and blisters.
Initial suspicion of cellulitis was incorrect; symptoms improved significantly after acetaminophen discontinuation.
The Naranjo scale indicated probable causality between acetaminophen and the observed GBFDE.

Conclusions:

Acetaminophen can induce generalized bullous fixed drug eruption, a severe adverse reaction.
Clinicians must consider acetaminophen as a potential cause of FDE, recognizing its diverse clinical manifestations.
Early diagnosis and withdrawal of acetaminophen are essential for effective management of this condition.